Pharmacokinetics and phenotyping properties of the Basel phenotyping cocktail combination capsule in healthy male adults
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چکیده
منابع مشابه
Comparison of Liver Cell Models Using the Basel Phenotyping Cocktail
Currently used hepatocyte cell systems for in vitro assessment of drug metabolism include hepatoma cell lines and primary human hepatocyte (PHH) cultures. We investigated the suitability of the validated in vivo Basel phenotyping cocktail (caffeine [CYP1A2], efavirenz [CYP2B6], losartan [CYP2C9], omeprazole [CYP2C19], metoprolol [CYP2D6], midazolam [CYP3A4]) in vitro and characterized four hepa...
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BACKGROUND AND OBJECTIVE Activity of human cytochrome P450 enzymes (CYPs) shows high inter-and intra-individual variability, which is determined by genetic and non-genetic factors. Using a combination of CYP-specific probe drugs, phenotyping cocktails allow simultaneous assessment of the activity of different CYP isoforms. The objective of this study was to characterize the phenotyping metrics ...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2019
ISSN: 0306-5251,1365-2125
DOI: 10.1111/bcp.14157